{\rtf1\deflang1033\deflangfe1033\margl720\margr720\margt360\margb360{\stylesheet{\fs20\lang1033\snext0 Normal;} {\s1\sb240\keepn{\*\pn \pnlvl1\pndec\pnprev1\pnstart1\pnsp144}\b\f0\fs30\lang1033 \sbasedon0\snext0 heading 1;} {\s2\sb200\keepn{\*\pn \pnlvl2\pndec\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs26\lang1033 \sbasedon0\snext0 heading 2;} {\s3\sb180\keepn{\*\pn \pnlvl3\pndec\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs22\lang1033 \sbasedon0\snext0 heading 3;} {\s4\sb160\keepn{\*\pn \pnlvl4\pnucltr\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs22\lang1033 \sbasedon0\snext0 heading 4;} {\s5\sb140\keepn{\*\pn \pnlvl5\pncltr\pnprev1\pnstart1\pnsp144}\b\f0\fs20\lang1033 \sbasedon0\snext0 heading 5;} {\s6\tqc\lang1033\sbasedon0\snext6 footer;} {\*\cs16 \additive\super\sbasedon10 footnote reference;} {\*\cs18 \additive\sbasedon10 page number;}} {\fonttbl{\f0\fnil Times New Roman;}{\f1\fnil Courier New}{\f2005\fnil Courier New;}{\f2010\fnil Wingdings;}{\f2020\fnil Webdings;}{\f2\fnil 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Washington, D.C. 20549\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\f0\fs4\par\pard\plain\f0\fs2\brdrt\brdrs\brdrw15\brdrcf2\brdrsp0\par\pard\plain\f0\fs4\par\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc FORM 8-K\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qc CURRENT REPORT\par\pard\plain\cf1\f51\fs20\b\qc PURSUANT TO SECTION 13 OR 15(d) OF THE\par\pard\plain\cf1\f51\fs20\qc SECURITIES EXCHANGE ACT OF 1934 \par\pard\plain\fs16\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\qc Date of Report (Date of earliest event reported): April 11, 2018\par\pard\plain\cf1\f51\fs20\qc \~ \par\pard\plain {\trowd\trqc\clbrdrb\brdrs\brdrcf1\cellx7560\trrh396 \pard\plain\intbl\li110\ri110\cf1\f51\fs32\b\qc TherapeuticsMD, Inc.\cell{ {\trowd\trqc\clbrdrb\brdrs\brdrcf1\cellx7560\trrh396\row}}}\pard\plain\cf1\f51\fs20\qc (Exact Name of Registrant as Specified in its Charter)\par\pard\plain\cf1\f51\fs20\qc \~\~\par\pard\plain\cf1\f51\fs20\qc \~ \par\pard\plain {\trowd\clbrdrb\brdrs\brdrcf1\cellx3456\cellx3672\clbrdrb\brdrs\brdrcf1\cellx7128\cellx7343\clbrdrb\brdrs\brdrcf1\cellx10800\trrh248 \pard\plain\intbl\li110\ri110\cf1\f51\fs20\b\qc Nevada\cell\pard\plain\intbl\li110\ri110\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li110\ri110\cf1\f51\fs20\b\qc 001-00100\cell\pard\plain\intbl\li110\ri110\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li110\ri110\cf1\f51\fs20\b\qc 87-0233535\cell{ {\trowd\clbrdrb\brdrs\brdrcf1\cellx3456\cellx3672\clbrdrb\brdrs\brdrcf1\cellx7128\cellx7343\clbrdrb\brdrs\brdrcf1\cellx10800\trrh248\row}}} {\trowd\cellx3456\cellx3672\cellx7128\cellx7343\cellx10800\trrh495 \pard\plain\intbl\cf1\f51\fs20\qc (State or Other\par\pard\plain\intbl\cf1\f51\fs20\qc Jurisdiction of Incorporation)\cell\pard\plain\intbl\li110\ri110\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li110\ri110\cf1\f51\fs20\qc (Commission File Number)\cell\pard\plain\intbl\li110\ri110\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\li110\ri110\cf1\f51\fs20\qc (IRS Employer \par\pard\plain\intbl\fs16\pard\plain\intbl\li110\ri110\cf1\f51\fs20\qc Identification No.)\cell{ {\trowd\cellx3456\cellx3672\cellx7128\cellx7343\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql \~ \par\pard\plain {\trowd\trqc\clbrdrb\brdrs\brdrcf1\cellx7560\trrh495 \pard\plain\intbl\cf1\f51\fs20\qc 6800 Broken Sound Parkway NW, Third Floor\par\pard\plain\intbl\cf1\f51\fs20\qc Boca Raton, FL 33487\cell{ {\trowd\trqc\clbrdrb\brdrs\brdrcf1\cellx7560\trrh495\row}}} {\trowd\trqc\cellx7560\trrh248 \pard\plain\intbl\li110\ri110\cf1\f51\fs20\qc (Address of Principal Executive Office) (Zip Code)\cell{ {\trowd\trqc\cellx7560\trrh248\row}}}\pard\plain\cf1\f51\fs20\qc \~\par\pard\plain\cf1\f51\fs20\qc Registrant's telephone number, including area code: (561) 961-1900\par\pard\plain\cf1\f51\fs20\qc \~\par\pard\plain\cf1\f51\fs20\qj Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the\plain\cf1\f51\fs20\qj registrant under any of the following provisions:\par\pard\plain\cf1\f51\fs20\qj \~ \par\pard\plain {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qj \u9744?\cell\pard\plain\intbl\cf1\f51\fs20\qj Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}} {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\cf1\f51\fs20\qj \~\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}} {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qj \u9744?\cell\pard\plain\intbl\cf1\f51\fs20\qj Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}} {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\cf1\f51\fs20\qj \~\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}} {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qj \u9744?\cell\pard\plain\intbl\cf1\f51\fs20\qj Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}} {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\cf1\f51\fs20\qj \~\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}} {\trowd\cellx664\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qj \u9744?\cell\pard\plain\intbl\cf1\f51\fs20\qj Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))\cell{ {\trowd\cellx664\cellx10800\trrh248\row}}}\pard\plain\fi264\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\qj Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of\plain\cf1\f51\fs20\qj 1933 (\u167? 230-405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (\u167?240.12b-2 of this chapter).\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\ql Emerging growth company \u9744?\par\pard\plain\cf1\f51\fs20\qr \~\par\pard\plain\cf1\f51\fs20\qj If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for\plain\cf1\f51\fs20\qj complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.\plain\cf1\f51\fs20\qj \u9744?\plain\cf1\f51\fs20\b\qj \~\par\pard\plain\cf1\f51\fs20\qj \~ \par\pard\plain {\trowd\clvertalc\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qc \~\cell{ {\trowd\clvertalc\cellx10800\trrh248\row}}} \page \par\pard\plain {\trowd\clvertalc\cellx10800\trrh248 \pard\plain\intbl\brdrb\brdrs\cf1\f51\fs20\qc \~\cell{ {\trowd\clvertalc\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~{\*\bkmkstart part_1_2_1}{\*\bkmkend part_1_2_1}{\*\bkmkstart item_1_45_1}{\*\bkmkend item_1_45_1} \par\pard\plain {\trowd\cellx1706\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\b\qj Item 7.01\cell\pard\plain\intbl\cf1\f51\fs20\b\qj Regulation FD Disclosure.\cell{ {\trowd\cellx1706\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\fi550\cf1\f51\fs20\qj On April 11, 2018, TherapeuticsMD, Inc., a Nevada corporation (the \u8220?Company\u8221?), issued a press release\plain\cf1\f51\fs20\qj announcing that the Company had entered into negotiations with the U.S. Food and Drug Administration (\u8220?FDA\u8221?)\plain\cf1\f51\fs20\qj regarding the proposed label for TX-004HR, the Company's investigational applicator-free estradiol vaginal softgel capsule for\plain\cf1\f51\fs20\qj the treatment of moderate-to-severe vaginal pain during sexual intercourse (dyspareunia), a symptom of vulvar and vaginal\plain\cf1\f51\fs20\qj atrophy (\u8220?VVA\u8221?) due to menopause. A copy of the press release is furnished as Exhibit 99.1 to this Current Report\plain\cf1\f51\fs20\qj on Form 8-K and is incorporated in this Item 7.01 by reference.\par\pard\plain\fi550\cf1\f51\fs20\qj \~\par\pard\plain\fi550\cf1\f51\fs20\qj The information in Items 7.01 and 9.01 of this Current Report on Form 8-K (including the exhibit) is furnished and shall\plain\cf1\f51\fs20\qj not be deemed to be \u8220?filed\u8221? for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended\plain\cf1\f51\fs20\qj (the \u8220?Exchange Act\u8221?), or otherwise subject to the liabilities of that section. The information in Items 7.01 and 9.01\plain\cf1\f51\fs20\qj of this Current Report shall not be incorporated by reference into any filing under the Securities Act of 1933, as amended, or the\plain\cf1\f51\fs20\qj Exchange Act, whether made before or after the date of this Current Report, regardless of any general incorporation language in\plain\cf1\f51\fs20\qj the filing.\par\pard\plain\fi550\cf1\f51\fs20\qj \~{\*\bkmkstart part_1_2_2}{\*\bkmkend part_1_2_2}{\*\bkmkstart item_1_47_1}{\*\bkmkend item_1_47_1} \par\pard\plain {\trowd\cellx1706\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\b\ql Item 9.01.\cell\pard\plain\intbl\cf1\f51\fs20\b\ql Financial Statements and Exhibits.\cell{ {\trowd\cellx1706\cellx10800\trrh248\row}}}\pard\plain\fi550\cf1\f51\fs20\qj \~ \par\pard\plain {\trowd\cellx253\cellx323\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qr (d)\cell\pard\plain\intbl\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\cf1\f51\fs20\i\qj Exhibits.\cell{ {\trowd\cellx253\cellx323\cellx10800\trrh248\row}}}\pard\plain\fi550\cf1\f51\fs20\i\qj \~ \par\pard\plain {\trowd\cellx1706\cellx3412\clvertalb\cellx10800\trrh495 \pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Exhibit \par\pard\plain\intbl\fs16\pard\plain\intbl\cf1\f51\fs20\ul\ql Number\cell\pard\plain\intbl\cf1\f51\fs20\ul\ql Description\cell{ {\trowd\cellx1706\cellx3412\clvertalb\cellx10800\trrh495\row}}} {\trowd\cellx1706\cellx3412\clvertalb\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{ {\trowd\cellx1706\cellx3412\clvertalb\cellx10800\trrh248\row}}} {\trowd\cellx1706\cellx3412\cellx10800\trrh495 \pard\plain\intbl\cf1\f51\fs20\qj \~\cell\pard\plain\intbl\cf1\f51\fs20\qj 99.1\cell\pard\plain\intbl\ul{\field{\*\fldinst HYPERLINK \\l "doc_1_2" }{\*\fldrslt\cf3\f51\fs20\qj Press Release from TherapeuticsMD, Inc., dated April 11, 2018, entitled}}\plain\intbl\ul{\field{\*\fldinst HYPERLINK \\l "doc_1_2" }{\*\fldrslt\cf3\f51\fs20\qj \u8220?TherapeuticsMD Enters Into Label Negotiations for TX-004HR.\u8221?}}\cell{ {\trowd\cellx1706\cellx3412\cellx10800\trrh495\row}}}\pard\plain\cf1\f51\fs20\qc \~\plain\cf1\f51\fs20\b\qc \~ \par\pard\plain {\trowd\clvertalc\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qc \~\cell{ {\trowd\clvertalc\cellx10800\trrh248\row}}} \page \par\pard\plain {\trowd\clvertalc\cellx10800\trrh248 \pard\plain\intbl\brdrb\brdrs\cf1\f51\fs20\qc \~\cell{ {\trowd\clvertalc\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\qc \~{\*\bkmkstart part_1_2_3}{\*\bkmkend part_1_2_3}\par\pard\plain\sa220\cf1\f51\fs20\b\qc SIGNATURES\par\pard\plain\fi550\cf1\f51\fs20\qj Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed\plain\sa264\cf1\f51\fs20\qj on its behalf by the undersigned hereunto duly authorized. \par\pard\plain {\trowd\cellx6358\cellx10799\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql Date:\~\~April 11, 2018\cell\pard\plain\intbl\cf1\f51\fs20\ql THERAPEUTICSMD, INC.\cell{ {\trowd\cellx6358\cellx10799\trrh248\row}}} {\trowd\cellx6358\cellx10799\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{ {\trowd\cellx6358\cellx10799\trrh248\row}}} {\trowd\cellx6358\cellx10799\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql \~\cell{ {\trowd\cellx6358\cellx10799\trrh248\row}}} {\trowd\cellx6358\cellx7293\clbrdrb\brdrs\brdrcf1\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql By:\cell\pard\plain\intbl\cf1\f51\fs20\ql /s/\plain\intbl\cf1\f51\fs20\i\ql Daniel A. Cartwright\cell{ {\trowd\cellx6358\cellx7293\clbrdrb\brdrs\brdrcf1\cellx10800\trrh248\row}}} {\trowd\cellx6358\cellx7293\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Name:\cell\pard\plain\intbl\cf1\f51\fs20\ql Daniel A. Cartwright\cell{ {\trowd\cellx6358\cellx7293\cellx10800\trrh248\row}}} {\trowd\cellx6358\cellx7293\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\ql \~\cell\pard\plain\intbl\cf1\f51\fs20\ql Title:\cell\pard\plain\intbl\cf1\f51\fs20\ql Chief Financial Officer\cell{ {\trowd\cellx6358\cellx7293\cellx10800\trrh248\row}}}\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\ql \~ \par\pard\plain {\trowd\clvertalc\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qc \~\cell{ {\trowd\clvertalc\cellx10800\trrh248\row}}}\pard\plain\brdrb\brdrs\cf1\f51\fs20\ql \~ \page{\*\bkmkstart doc_1_2}{\*\bkmkend doc_1_2}\par\pard\plain\brdrb\brdrs\cf1\f51\fs2\ql \~\pard\plain\ul{\field{\*\fldinst HYPERLINK \\l "doc_1_1" }{\*\fldrslt\cf3\f51\fs20\ql TherapeuticsMD, Inc. 8-K}}\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\cf1\f51\fs20\b\qr Exhibit 99.1\par\pard\plain\cf1\f51\fs20\ql \~\par\qr\li6908\sb88{\*\shppict{\pict\pngblip\picw273\pich34\picscalex74\picscaley68\bliptag-259107101043 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\par\pard\plain\ri1936\sb44\cf1\f51\fs20\ql FOR IMMEDIATE RELEASE\par\pard\plain\cf1\f51\fs20\ql \~\par\pard\plain\li88\ri88\cf1\f51\fs20\b\qc TherapeuticsMD Enters Into Label Negotiations for TX-004HR\par\pard\plain\li88\ri88\cf1\f51\fs20\b\qc \~\par\pard\plain\cf1\f51\fs20\b\qj BOCA RATON, Florida, April 11, 2018\plain\cf1\f51\fs20\qj \u8211? TherapeuticsMD, Inc. (NASDAQ: TXMD), an innovative women\u8217?s\plain\cf1\f51\fs20\qj healthcare company, today announced that the Company has entered into negotiations with the U.S. Food and Drug\plain\cf1\f51\fs20\qj Administration (FDA) regarding the proposed label for TX-004HR, the Company\u8217?s investigational applicator-free\plain\cf1\f51\fs20\qj estradiol vaginal softgel capsule for the treatment of moderate-to-severe vaginal pain during sexual intercourse (dyspareunia), a\plain\cf1\f51\fs20\qj symptom of vulvar and vaginal atrophy (VVA) due to menopause. As previously announced, the Prescription Drug User Fee Act\plain\cf1\f51\fs20\qj (PDUFA) target action date for the completion of the FDA\u8217?s review of the new drug application (NDA) for TX-004HR is\plain\cf1\f51\fs20\qj May 29, 2018. The Company does not anticipate providing subsequent updates with respect to label negotiations prior to the\plain\cf1\f51\fs20\qj PDUFA target action date. There can be no assurance that the FDA will approve the NDA for TX-004HR, or that such approval\plain\cf1\f51\fs20\qj will occur by the PDUFA target action date, and the entrance into label negotiations does not imply otherwise.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\qj About TherapeuticsMD, Inc.\par\pard\plain\cf1\f51\fs20\b\qj \~\par\pard\plain\cf1\f51\fs20\qj TherapeuticsMD, Inc. is an innovative healthcare company focused on developing and commercializing products exclusively for\plain\cf1\f51\fs20\qj women. With its SYMBODA\u8482? technology, TherapeuticsMD is developing advanced hormone therapy pharmaceutical\plain\cf1\f51\fs20\qj products to enable delivery of bio-identical hormones through a variety of dosage forms and administration routes. The\plain\cf1\f51\fs20\qj Company\u8217?s late stage clinical pipeline includes two product candidates that have completed phase 3 trials and are awaiting\plain\cf1\f51\fs20\qj approval by the FDA: TX-001HR for treatment of moderate-to-severe vasomotor symptoms (VMS) due to menopause and\plain\cf1\f51\fs20\qj TX-004HR for treatment of moderate-to-severe vaginal pain during sexual intercourse (dyspareunia), a symptom of vulvar and\plain\cf1\f51\fs20\qj vaginal atrophy (VVA) due to menopause. The Company also manufactures and distributes branded and generic prescription\plain\cf1\f51\fs20\qj prenatal vitamins under the vitaMedMD\u174? and BocaGreenMD\u174? brands.\par\pard\plain\cf1\f51\fs20\qj \~\par\pard\plain\cf1\f51\fs20\b\qj Forward-Looking Statements\par\pard\plain\cf1\f51\fs20\b\qj \~\par\pard\plain\cf1\f51\fs20\i\qj This press release by TherapeuticsMD, Inc. may contain forward-looking statements. Forward-looking statements may include,\plain\cf1\f51\fs20\i\qj but are not limited to, statements relating to TherapeuticsMD\u8217?s objectives, plans and strategies as well as statements,\plain\cf1\f51\fs20\i\qj other than historical facts, that address activities, events or developments that the company intends, expects, projects, believes or\plain\cf1\f51\fs20\i\qj anticipates will or may occur in the future. These statements are often characterized by terminology such as\plain\cf1\f51\fs20\i\qj \u8220?believes,\u8221? \u8220?hopes,\u8221? \u8220?may,\u8221? \u8220?anticipates,\u8221? \u8220?should,\u8221?\plain\cf1\f51\fs20\i\qj \u8220?intends,\u8221? \u8220?plans,\u8221? \u8220?will,\u8221? \u8220?expects,\u8221? \u8220?estimates,\u8221?\plain\cf1\f51\fs20\i\qj \u8220?projects,\u8221? \u8220?positioned,\u8221? \u8220?strategy\u8221? and similar expressions and are based on\plain\cf1\f51\fs20\i\qj assumptions and assessments made in light of management\u8217?s experience and perception of historical trends, current\plain\cf1\f51\fs20\i\qj conditions, expected future developments and other factors believed to be appropriate. Forward-looking statements in this press\plain\cf1\f51\fs20\i\qj release are made as of the date of this press release, and the company undertakes no duty to update or revise any such\plain\cf1\f51\fs20\i\qj statements, whether as a result of new information, future events or otherwise. Forward-looking statements are not guarantees of\plain\cf1\f51\fs20\i\qj future performance and are subject to risks and uncertainties, many of which are outside of the company\u8217?s control.\plain\cf1\f51\fs20\i\qj Important factors that could cause actual results, developments and business decisions to differ materially from forward-looking\plain\cf1\f51\fs20\i\qj statements are described in the sections titled \u8220?Risk Factors\u8221? in the company\u8217?s filings with the Securities and\plain\cf1\f51\fs20\i\qj Exchange Commission, including its most recent Annual Report on Form 10-K and Quarterly Reports on Form 10-Q, as well\plain\cf1\f51\fs20\i\qj as reports on Form 8-K, and include the following: the company\u8217?s ability to resolve the deficiencies identified by the\plain\cf1\f51\fs20\i\qj FDA in the company\u8217?s new drug application for its TX-004HR product candidate and the time frame associated with\plain\cf1\f51\fs20\i\qj such resolution; whether the FDA will approve the amended NDA for the company\u8217?s TX-004HR product candidate and\plain\cf1\f51\fs20\i\qj whether such approval will occur by the PDUFA target action date; whether the FDA will approve the NDA for the\plain\cf1\f51\fs20\i\qj company\u8217?s TX-001HR product candidate and whether such approval will occur by the PDUFA target action date; the\plain\cf1\f51\fs20\i\qj company\u8217?s ability to maintain or increase sales of its products; the company\u8217?s ability to develop and commercialize\plain\cf1\f51\fs20\i\qj its hormone therapy drug candidates and obtain additional financing necessary therefor; the length, cost and uncertain results of\plain\cf1\f51\fs20\i\qj the company\u8217?s clinical trials, including any additional clinical trials that the FDA may require in connection with\plain\cf1\f51\fs20\i\qj TX-004HR; the potential of adverse side effects or other safety risks that could preclude the approval of the company\u8217?s\plain\cf1\f51\fs20\i\qj hormone therapy drug candidates; the company\u8217?s reliance on third parties to conduct its clinical trials, research and\plain\cf1\f51\fs20\i\qj development and manufacturing; the availability of reimbursement from government authorities and health insurance companies\plain\cf1\f51\fs20\i\qj for the company\u8217?s products; the impact of product liability lawsuits; the influence of extensive and costly government\plain\cf1\f51\fs20\i\qj regulation; the volatility of the trading price of the company\u8217?s common stock and the concentration of power in its stock\plain\cf1\f51\fs20\i\qj ownership. PDF copies of the company\u8217?s historical press releases and financial tables can be viewed and downloaded at\plain\cf1\f51\fs20\i\qj its website: www.therapeuticsmd.com/pressreleases.aspx.\par\pard\plain\cf1\f51\fs20\qc \~\par\pard\plain\cf1\f51\fs20\qc # # #\par\pard\plain\li110\fi-110\cf1\f51\fs20\ql \~\par\pard\plain\li110\fi-110\cf1\f51\fs20\b\ul\ql Investor Contact\par\pard\plain\ri6424\cf1\f51\fs20\ql \~\par\pard\plain\ri6424\cf1\f51\fs20\ql David DeLucia\par\pard\plain\ri6424\cf1\f51\fs20\ql Director, Investor Relations\par\pard\plain\cf1\f51\fs20\qj 561-961-1900 \par\pard\plain\fs16\pard\plain\cf1\f51\fs20\qj David.DeLucia@TherapeuticsMD.com\par\pard\plain\cf1\f51\fs20\qj \~ \par\pard\plain {\trowd\clvertalc\cellx10800\trrh248 \pard\plain\intbl\cf1\f51\fs20\qc \~\cell{ {\trowd\clvertalc\cellx10800\trrh248\row}}}\pard\plain\brdrb\brdrs\cf1\f51\fs20\qj \~}