{\rtf1\deflang1033\deflangfe1033\margl720\margr720\margt360\margb360{\stylesheet{\fs20\lang1033\snext0 Normal;} {\s1\sb240\keepn{\*\pn \pnlvl1\pndec\pnprev1\pnstart1\pnsp144}\b\f0\fs30\lang1033 \sbasedon0\snext0 heading 1;} {\s2\sb200\keepn{\*\pn \pnlvl2\pndec\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs26\lang1033 \sbasedon0\snext0 heading 2;} {\s3\sb180\keepn{\*\pn \pnlvl3\pndec\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs22\lang1033 \sbasedon0\snext0 heading 3;} {\s4\sb160\keepn{\*\pn \pnlvl4\pnucltr\pnprev1\pnstart1\pnsp144{\pntxtb.}}\b\f0\fs22\lang1033 \sbasedon0\snext0 heading 4;} {\s5\sb140\keepn{\*\pn \pnlvl5\pncltr\pnprev1\pnstart1\pnsp144}\b\f0\fs20\lang1033 \sbasedon0\snext0 heading 5;} {\s6\tqc\lang1033\sbasedon0\snext6 footer;} {\*\cs16 \additive\super\sbasedon10 footnote reference;} {\*\cs18 \additive\sbasedon10 page number;}} {\fonttbl{\f0\fnil Times New Roman;}{\f1\fnil Courier New}{\f2005\fnil Courier New;}{\f2010\fnil Wingdings;}{\f2020\fnil Webdings;}{\f2\fnil Arial;}{\f3\fnil Arial;}{\f4\fnil LucidaHandwriting;}{\f5\fnil Symbol;}{\f6\fnil Symbol;}{\f7\fnil Ferdsch;}{\f30\fnil Myriad Cn Semibold;}{\f31\fnil Myriad Roman;}{\f50\fnil Courier New;}{\f51\fnil Times New Roman;}{\f52\fnil Arial;}{\f53\fnil Symbol;}{\f54\fnil Wingdings;}{\f55\fnil Wingdings 2;}{\f56\fnil Wingdings 3;}{\f57\fnil Webdings;}{\f58\fnil Arial Narrow;}{\f59\fnil Arial Unicode MS;}{\f60\fnil Cyberbit;}{\f61\fnil Morningstar 1U Light;}{\f62\fnil Calibri;}} {\colortbl;\red0\green0\blue0;\red127\green0\blue0;\red0\green0\blue255;\red127\green127\blue127;\red0\green51\blue153;\red255\green204\blue0;\red255\green255\blue255;\red246\green244\blue236;\red0\green0\blue0;} {\*\bkmkstart filing_1}{\*\bkmkend filing_1}{\*\bkmkstart doc_1_1}{\*\bkmkend doc_1_1} \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql UNITED STATES \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql SECURITIES AND EXCHANGE COMMISSION \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Washington, D.C. 20549 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql SCHEDULE 13G \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Under the Securities Exchange Act of 1934 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (Amendment No. 4) \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql TherapeuticsMD, Inc. \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (Name of Issuer) \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql COMMON STOCK \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (Title of Class of Securities) \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 88338N107 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (CUSIP NUMBER) \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql December 31, 2017 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (Date of Event which Requires Filing of Statement) \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Check the appropriate box to designate the Rule pursuant to which this \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Schedule is filed: \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql [x] Rule 13d - 1(b) \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Rule 13d - 1(c) \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Rule 13d - 1(d) \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 1. Name of Reporting Person \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql T. ROWE PRICE ASSOCIATES, INC. \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 52-0556948 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 2. Check the Appropriate Box if a Member of a Group \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql NOT APPLICABLE \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 3. SEC Use Only \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 4. Citizenship or Place of Organization \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Maryland \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Number of Shares Beneficially Owned by Each Reporting Person With \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 5. Sole Voting Power* 3,220,088 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 6. Shared Voting Power* 0 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 7. Sole Dispositive Power* 17,431,395 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 8. Shared Dispositive Power 0 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 9. Aggregate Amount Beneficially Owned by Each Reporting Person \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 17,431,395 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 10. Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql NOT APPLICABLE \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 11. Percent of Class Represented by Amount in Row 9 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 8.0% \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 12. Type of Reporting Person \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql IA \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql *Any shares reported in Items 5 and 6 are also reported in Item 7. \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 1(a) Name of Issuer: \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql TherapeuticsMD, Inc. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 1(b) Address of Issuer's Principal Executive Offices: \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 6800 BROKEN SOUND PARKWAY NW \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql THIRD FLOOR \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql BOCA RATON, FLORIDA 33487 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 2(a) Name of Person(s) Filing: \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (1) T. ROWE PRICE ASSOCIATES, INC. ("Price Associates") \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 2(b) Address of Principal Business Office: \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 100 E. Pratt Street, Baltimore, MD 21202 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 2(c) Citizenship or Place of Organization: \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (1) Maryland \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 2(d) Title of Class of Securities: COMMON STOCK \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 2(e) Cusip Number: 88338N107 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 3: The person filing this Schedule 13G is an: \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql X Investment Adviser registered under Section 203 of the Investment \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Advisers Act of 1940 \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 4: Reference is made to Items 5-11 on the preceding pages of this \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Schedule 13G. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 5: Ownership of Five Percent or Less of a Class \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Not Applicable \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 6: Ownership of More than Five Percent on Behalf of Another Person \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (1) Price Associates does not serve as custodian of the assets of any of \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql its clients; accordingly, in each instance only the client or the \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql client's custodian or trustee bank has the right to receive dividends \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql paid with respect to, and proceeds from the sale of, such securities. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql The ultimate power to direct the receipt of dividends paid with \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql respect to, and the proceeds from the sale of, such securities, is \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql vested in the individual and institutional clients which Price \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Associates serves as investment adviser. Any and all discretionary \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql authority which has been delegated to Price Associates may be revoked \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql in whole or in part at any time. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Except as may be indicated if this is a joint filing with one of the \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql registered investment companies sponsored by Price Associates which it \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql also serves as investment adviser ("T. Rowe Price Funds"), not more \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql than 5% of the class of such securities is owned by any one client \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql subject to the investment advice of Price Associates. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql (2) With respect to securities owned by any one of the T. Rowe Price \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Funds, only the custodian for each of such Funds, has the right to \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql receive dividends paid with respect to, and proceeds from the sale of, \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql such securities. No other person is known to have such right, except \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql that the shareholders of each such Fund participate proportionately \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql in any dividends and distributions so paid. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 7: Identification and Classification of the Subsidiary Which Acquired the \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Security Being Reported on By the Parent Holding Company. \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Not Applicable \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 8: Identification and Classification of Members of the Group \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Not Applicable \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 9: Notice of Dissolution of Group \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Not Applicable \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Item 10: Certification \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql By signing below I certify that, to the best of my knowledge and \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql belief, the securities referred to above were acquired in the \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql ordinary course of business and were not acquired and are not \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql held for the purpose of or with the effect of changing or \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql influencing the control of the issuer of the securities and were \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql not acquired and are not held in connection with or as a participant \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql in any transaction having that purpose or effect. T. Rowe Price \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Associates, Inc. hereby declares and affirms that the filing \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql of Schedule 13G shall not be construed as an admission that Price \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Associates is the beneficial owner of the securities referred to, \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql which beneficial ownership is expressly denied. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Signature. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql After reasonable inquiry and to the best of my knowledge and belief, \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql I certify that the information set forth in this statement is true, \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql complete and correct. \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql T. ROWE PRICE ASSOCIATES, INC. \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Date: February 14, 2018 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Signature: /s/ David Oestreicher \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql Name & Title: David Oestreicher, Vice President \par\pard\plain\fs16 \par\pard\plain\fs16\pard\plain\cf1\f50\fs16\ql 12/31/2017 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16 \par\pard\plain\fs16}